HORDB

ID: hor001034
Uniprot ID: F1LHM7
Protein name: Neuropeptide PF4
Gene name: NA
Organism: Ascaris suum (Pig roundworm) (Ascaris lumbricoides)
Family: FMRFamide related peptide family
Source: animal
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Ascaris (genus), Ascarididae (family), Ascaridoidea (superfamily), Ascaridomorpha (infraorder), Spirurina (suborder), Rhabditida (order), Chromadorea (class), Nematoda (phylum), Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: KPNFIRF
Length: 7
Propeptide: MMRQSHSVMSPYYVALFLIFCSSQVLGECCNDGQTSDFCAVFNMLSPTEQAEVRSYLGDNCDGDADEAVRKIEKRKPNFIRFGRTAPPLTFGKKGSDPNFLRFG
Signal peptide: MMRQSHSVMSPYYVALFLIFCSSQVLG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Elicit a potent, inhibition of Ascaris muscle cells which is partially mediated by chloride
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: muscle cells:98 nM
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor001034_AF2.pdb

hor001034_ESM.pdb

Mass:	102830	Formula:	C45H68N12O9
Absent amino acids:	ACDEGHLMQSTVWY	Common amino acids:	F
pI:	11.65	Basic residues:	2
Polar residues:	1	Hydrophobic residues:	3
Hydrophobicity:	-48.57	Boman Index:	-1623
Half-Life:	1.3 hour	Half-Life Yeast:	3 min
Half-Life E.Coli:	2 min	Aliphatic Index	55.71
Instability Index:	-2367.14	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 9031739
Title: The peptidergic nervous system of the triclad turbellarian, Bdelloura candida (Maricola, Bdellouridae): an immunocytochemical study using an antiserum raised to an endogenous neuropeptide, GYIRFamide.